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Ilyinskaya GV, Komarov PG, Agapova LS, Kochetkov DV, Strom E et al(2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through ap73-dependent salvage pathway. The mass iscontaining calci? cations ( curved arrow). However, this protein may be involved in potentiation of themetastatic process as well as its inhibition, and its actual function may depend onthe concentration in the microenvironment and the context in which it is expressed.For example, at physiological levels it acts to promote angiogenesis and cellularinvasion, whereas elevated concentrations are inhibitory [ 27], and may act to aidcellular detachment [ 28] in an integrin-dependent manner [ 29]
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